Claire Corlett

Fish Food, Fish Tanks, and More
Dave Feldman – ‘It’s About Energy, Not Cholesterol’

Dave Feldman – ‘It’s About Energy, Not Cholesterol’


so I’m gonna I’ve had to cut down about ninety minutes of material to 30 minutes so this is gonna be pretty nutrient-dense just gonna warn you in advance so this is me I’m not gonna spend too much time on the back story but I started Aikido in April of 2015 and I had a little over half a year of pure bliss it was fantastic and then of course I got the huge cholesterol score and I found out I was a hyper responder show of hands how many people who are hyper responders ah interesting we’ll talk more about that in a second then I started beginning I began studying every single thing that I could about cholesterol and a lipid system and as a software engineer I saw a pattern which I’m going to talk to you about now first of all I then started in when we say biohacking we have to start with data so I actually photograph every single thing I ingest in fact I have a standing bet with every single conference I go to now if you can catch me ingesting one thing that I didn’t take a photo of I’ll give you $100 I have yet to pay that out by the way I’ve also done 82 blood tests in almost two years time eighty two blood tests why do I do this because then I get to make beautiful graphs like this now what you’re looking at is a relative comparison of the first data points that I had in which I was on a ketogenic diet for the first nine months of my experimentation and had this pattern not arose I would just be a private citizen right now who knows I might even be on a statin but I doubt it on the left side what you’re seeing is a three-day average of dietary fat and on the right side you’re seeing the resulting LDL see from the three days before let me add some extra emphasis you’re only seeing that window of three days all the days before that are not on this graph so this may sound a little odd but what I did was is I controlled for exercise I controlled for energy expenditures and other methods and in doing so I found that through the homeostasis without question we have a massive correlation I can show you this by flipping that axes on the left side and you can see the in verse correlation very tightly as you can see from the Pearson and for the regression for those of you who are geeks you can see just how tight it is well I’m gonna tell this story over three major experiments the first one being the identical diet experiment that I managed to talk my sister who’s shown here on the Left into doing and once again AB super high cholesterol I didn’t get a chance to convert this one to your units yet but trust me well into the hyper responder territory right she has almost half of my cholesterol even though she’s six and a half years older she adopted the ketogenic diet because her profile was so much less I managed to talk her into doing this experiment where we would be eating exactly the same amount of food exactly the same times and then get our blood drawn at exactly the same times as well this is how much she loves her brother we did this for 13 days and we took seven blood draws total so what do you suppose happened when you compare our blood results in absolute terms you see it mines way up above however when you compare hers and mine against the dietary fat we had I specifically had us eat to a diet plan so that we can induce these curves so that they could be shown now what happens when we do a relative comparison between hers and mine hers is on the left and as you can see it’s of a different magnitude than mine that’s on the right but the correlation is striking if we go a step further we look at just ldl-c you can likewise see incredibly credibly tight Pearson correlation completely completely different metabolisms right same thing with absolute comparisons between HDL see these so-called good cholesterol and of course triglycerides again with an absolute comparison okay not only jumps do not jump to another experiment the extreme drop experiment this took place one year ago tomorrow this is the first public presentation of my data I was so young and naive then right but I was so confident on the inverse pattern that at the key to gain seminar where I gave this on October 9th I had already taken my blood two days earlier on October 7th and I said to everybody there I bet my reputation everything that I’ve got on the fact that when I take my blood tomorrow on October 10th it’s gonna show a massive shift in cholesterol going down and they watched me through the conference’s I was chowing down steak and butter and a DAP meal and all kinds of things that were high fat so that basically I was able to reach having first low and then hitting about 461 grams of fat each day through the conference so what happened to my cholesterol gorging on all of that fat 274 grams of it being saturated my numbers dropped my total cholesterol dropped these are all converted for you for you fine folks my ldl-c dropped by 1.9 my LDL P dropped by a thousand 115 points you’ll find all sorts of articles on the internet on all sorts of different hacky ways to lower it I’m telling you that I knew having massive amounts of fat ingested and controlling for all the other variables would result in this massive drop for those imperial imperialists in the room you can also see the version that’s in milligrams per deciliter all right third and final experiment to really drive this home there happened to be this other little conference called keto fest where I managed to get fine folks at pts Diagnostics to help pay for lab results in addition to their fine device the cardio check have to give them a little bit of a plug because they paid for all of the support on this and somehow I talked two dozen people into following this diet plan which is an adaptation of the experiment you just saw before we had low calorie but low carb high fat or full-blown fasting for three days and then we shifted it over to high calorie low carb high fat which was pretty easy to do through keto fest turns out everybody took a blood test on the Friday morning before the Kido fest started everybody took a blood test at the end and I posted my hypothesis in advance in the conditions in my experiment because I learned in second grade that that’s how science is supposed to be conducted just thought I would fit that in there we then went ahead and gorged on beauties like this some fatty steaks right and as you could see we’d let just about anybody into this experiment then what happened what were the results huge profile over two dozen people one person unfortunately fell off and one person had unusually low hdl-c which confound the experiments that we had a total of 22 pristine that we were able to report on and this is what I like to call the tilted ladder over here on the left on was Friday on Friday 7 14 17 this was their initial starting ldlc on the right side is the resulting three days later resulting Monday 717 results and as you can see sure three had an increase of one to two percent the remaining 19 had a decrease of between five and 38 percent in three days all right as you can see this drop is 16% across the board everybody here that’s in blue saw a drop how would I know that my hypothesis was gonna fit that well now I’m gonna get to the inversion pattern this is what I’m talking about and I’m gonna kind of get to what it is behind it but first I need to break it down for you so once again this is being filmed on Sunday morning if I took my blood this morning I would look backwards three days I’d look back to Saturday yesterday the day before that Friday in the day before that Thursday and I would find that that three day window would have the most impact on what my resulting ldl-c score was from this morning in an inversion as an the more fat that I ate the lower my cholesterol would be right all right so here’s the theory this is Occam’s razor but thus far the data seems to keep showing that this is got a lot of merit to it but first I want to get into the anatomy a cutesy anatomy of the low density lipoprotein I want you to understand these three parts okay so this the LDL P low-density lipoprotein particle itself is a boat you hear it described as such so it can be hydrophilic it can move through the bloodstream natively it needs to because the inside of it is lipophilic that’s how fats can get into your blood to be able to get to the cells that need it right and there’s actually a lot more things on here than just triglycerides and cholesterol but what’s the primary payload what is it anyone triglycerides triglycerides now what’s the secondary payload cholesterol okay we’re gonna come back to that because what ever one on a low-carb high-fat diet should know is that a low-density lipoprotein has many jobs can could speak to this a lot more than I can has many different jobs but its primary job its primary job is to distribute energy from fat let me all caps bold face underline that and anybody who’s watched this video knows what’s coming let me deep it in one more slide it’s 3d it’s extruded and I’m gonna spend forever for the rest of my life trying to emphasize the primary purpose of a low-density lipoprotein is to distribute energy from fat and everyone loves this analogy so I’m gonna use it once again if you were to look at a cruise ship right and the boat is the low-density lipoprotein what are the triglycerides it’s the passengers yes what’s the cholesterol it’s the life rafts the life rafts are there for an emergency right but most cruise ships that are going out with their life rafts are they coming back with their life rafts yeah they are now if I were to say hey the primary purpose of a cruise ship is to move around life rafts does that sound right no but it is an important job of a cruise ship to move around life rats because you wouldn’t get on a cruise ship if there weren’t in life if there weren’t life rafts however if you were to observe a cruise ship from outer space you were in a lane you were like I wonder what these these boats are that are moving around what would you be seeing the most activity you’d be seeing you’d be seeing passengers getting on and off well if you look at low-density lipoproteins without question not only is their biggest payload triglycerides their first job is to drop off triglycerides that’s why me as a software engineer who’s worked on systems for ever thought that this was extremely obvious in the first three days I was starting to read it and yet I’m telling you right now they never say things like provide or fuel to the cells they usually say things like lost or leaked for how the triglycerides ultimately get off of this yeah I believe me that’s something that’s an endless well that I could talk about forever so let’s break apart low-density lipoproteins into the two classifications this will help it make more sense to you the first kind called chylomicrons and your can talk about this a little bit from before they’re basically the low-density lipoproteins carrying energy from food you just ate and I like to call them the sprinters because they actually go away pretty quickly depending on who you read they could go as long as a few hours but generally they’re gone in minutes they very quickly drop off their triglycerides become kind of micro and remanence and they go home where’s home the liver the liver is the one that ultimately absorbs it now the other kind are vldls they come from the liver now some of it is recirculated vldls from food you just say but generally speaking if your fasted these are the ones you’re gonna find and why is this so relevant it’s so relevant because if you take a cholesterol test you’re supposed to be fasted for how long at 12 hours right so only only low-density lipoproteins that are coming from storage are left over chylomicrons are gone right therefore it makes more sense than ever that when you’re getting a cholesterol test if I’m doing something like doing a multi-day fast that’s when my cholesterol is the highest because it’s up regulating fat from storage and guess what rides shares with fat from storage in low density lipoproteins cholesterol okay so let’s pretend for a moment with this inversion pattern that the body is looking back at this 3-day sample of time because this again comes back to the theory it appears as if there’s lots and lots of incoming energy coming from the GI tract it says well we’re in a state of abundance is there any good reason to mobilize fat no fat from your adipose tissue can just stay where it’s at because you’re taking in lots of existing dietary energy becomes chylomicrons the kind of microns get cleared ID at my blood I get my blood cholesterol test the next morning hey my cholesterol is really low but let’s can let’s change it say that we’re in a state of scarcity right you don’t have very much food coming under your full blown fasting well then the body has a good reason to mobilize more energy from fat right so the inversion pattern I’m not going to get too into all these bullet points to save time the inversion pattern appears to account for around 30 to 50 percent of your resulting ldlc score and this is an in version the higher your dietary fat the lower your resulting ldl-c and conversely the lower your dietary fat the higher your LDL C moreover the remaining 50 to 70% does appear to have more to do with energy composition the kind of diet you have exercise in metabolic status and that remaining half is what I’m currently experimenting on now so let’s dig a little bit deeper and talk about how this really is all about energy these three things we talked about plenty or at least you’ve probably already seen videos and have read about all the time carbs can get turned into glucose know about that you probably already heard protein can get turned into glucose for your gluconeogenesis and boy-oh-boy do we love to talk about how fat gets turned into ketones after all you’re on a ketogenic diet right I would argue you’re not on a ketogenic diet I would argue that you’re on a fatty acid diet because nobody likes to talk about these three like I do in the fact that fatty acids have a way of getting direct to your cells you are made up of a hundred trillion cells give or take a dozen trillion and there’s not one engine inside you there’s somewhere around a hundred trillion little engines inside you and they all need regular energy so all of these pathways by which you can get energy are important now before I can get to the next part this is the key concept I want you all to understand it’s one we can relate to by the way if FedEx is not a sponsor of my work it’s just we all know FedEx so we know how this works we know that FedEx is sending out its packages throughout the world and it gives it to local facilities and the local facilities is they’re getting it from the global distribution put them on much smaller vehicles they can get them out to the neighborhood houses and the businesses that need them right okay this is the global distribution this is the local distribution now that you’ve got that concept in your mind I’m just going to tweak it and now we’re gonna talk about this what’s your global distribution vehicle it’s in low-density lipoprotein it can start from the gutter it can start in the liver but you know what it can get to just about anywhere via your vascular system right what is your local distributor its adipose tissue your body fat and in particular your subcutaneous fat isn’t it amazing how systemically we happen to place fat cells all throughout our body I know a lot of you people are like I hate that I hate that fat but that local distributor gets something called Methos non-esterified fatty acids out to nearby cells right and I can’t get too much of the details without getting to Kiki but Methos are free fatty acids and just like triglycerides they don’t move easily in the blood so they need a little bit help but they’re helped a lot by just being very local to the tissues they’re trying to supply the energy to so this is the only slide where I have an existing study and I’m sorry I’m gonna translate some of this language for you it gets a bit geeky but if you were to go to an adipose tissue cell today and you were to say hey where did you get most of your energy from today it would say well I got them from a triglyceride that came off of a low-density lipoprotein boat right and they if you were to go next door to the muscle tissue you were to say to that cell hey how much how much triglycerides did you get from that same low-density lipoprotein boat and it would say oh I got some but actually was only a third of the energy that I got today well where did you get most of your energy from I got it from an honest terrified fatty acid of free fatty acid well how did that get to you it got to me from the nearby adipose tissue the local distributor of my available energy right all right now let me tie this all together bear with me we’re now talking fed state fasted state and this will all make sense so this little meter over here is gonna show us when we move over to fed state and when we’re looking at a post issue we’re looking at muscle tissue we had incoming energy from our diet right we’re on a high-fat diet here we go we’ve got load into lipoproteins in the form of chylomicrons in this case and they’re providing energy yes to our muscle tissue that’s where we wanted it to go but mostly mostly they’re providing energy to adipose tissue darn it they’re providing energy to our adipose tissue as a systems guy I get so annoyed by this because I find that these stereotypes perpetuate against what is clearly a very harmonious system and this is and as a guy who’s worked on systems for decades this is one of the most amazing things I’ve ever started reading into I’ve genuinely I’m excited about it I know you’re gonna say that you’re getting excited about lipids Dave because you have a lot of them that’s true but truly this system is really a symphony so once again low density lipoproteins delivering triglycerides to adipose tissue in the Fed state naturally we already know the rest of the story and the fasted State adipose tissue changes gear it’s local distribution now needs to keep that energy going up towards muscle tissue needs to be available and to some smaller degree low density lipoproteins usually provide the energy past this point for most people so the key the key is the wide availability of energy to cells it’s crucial I want you to think like an engineer with me understand the reason I put all this work into this is because I need to get you to understand this one thing the one thing that’s going to kill you is running out of energy if you know that if you know that no amount of viruses no amount of different problems all of those are much more survivable than the lights going out so all of your all of your system its first priority is to be sure that all of these hundred trillion engines have wide access to energy at any given time if you think about it from that perspective if you understand the problem and the solution that it is to the problem almost all of this will start making sense to you because that’s the core of it so I now get to show you the emerging patterns that I’ve gotten from having this website and the cholesterol that comes in and now it’s going to make more sense to you if I’ve been able to get this part across to you right before we do though I need to say hold it because if you’re not metabolically healthy the following patterns are less likely to apply and what do I mean by that well let’s go back to this model again we’re in the fed state what happens if we’re having trouble getting over to the fasted State right well obviously the adipose tissue needs to keep getting as much energy as it can and as it’s doing so it eventually becomes resistant I’ve actually got as much as I can really take on right so what happens to LDL particles that are looking for places to drop it off you get more and more of them so once again back to what Ken was talking about yesterday you have a whole bunch of vldls the ones that came from storage their job is to drop off the energy which you have a full-blown system that’s ready to handle it and you’ve managed to find a way to stay in a perpetual Fed state why do they think they’re in a Fed State even when your glucose is lower because your insulin is high your insulin so high it’s constantly signaling out to your whole system no no no no we’re in a state of abundance we’re in a state of abundance we’re in a state of abundance you’re locked and that’s why I can’t speak as much to why you would have higher LDL if you are in a perpetual Fed state but you know what the big giveaway is darn ken took it from me it’s high triglycerides because now you know high triglycerides triglycerides are the energy you’re feeding your cells there’s no good reason for you to have a lot of energy part in the bloodstream be it glucose or be it triglycerides there’s no good engineering reason and that’s the big giveaway if your triglycerides are high you know that you may be metabolically unhealthy so let’s say you are metabolically healthy right now what happens as you move from being overweight to lean what do you suppose the pattern is with your cholesterol does it go up or down goes up but what about your energy demands is you move from being sedentary to having high energy demands what do you suppose we see with cholesterol goes up now a lot of you guys have got to be shaking your heads right now right scratching your heads okay let’s go back to this model again as again a little bit simplified but as we move from the Fed state to the fasted State now let’s change one thing you have less adipose mass so now your local distributor of energy is providing less energy on a constant demand but again the priority is that you always have plenty of energy to provide yourselves right there’s this one other catch because your low-carb your muscle tissues both in the glycogen the muscle both in your skeletal muscle and in your liver aren’t empty but they’re not as high relative to somebody who’s on a carb centric diet so that energy is missing were you going to come up with the energy you up your global supply of energy so you actually have a systemically good reason to actually provide more energy directly from the global distributor enter what I call the lean mass hyper responder now when I posted this back in July it was half theoretical and half based on the data that I was getting back and to date it’s got more comments than any other blog post a half on my entire site something around 240 last I looked people are constantly writing in from all over the world they’re going this is me this is my pattern an LDL of 200 or higher sorry I didn’t get a chance to convert these four units but that’s extremely high that that hits familiar hypercholesterolemia levels or higher HDL HDL of 80 or higher and had a had a little more time I could get into why that has to do with the energy distribution as well but here’s the key triglycerides seventy or lower very low triglycerides now put this all together your LDL being really high means on a per particle basis total cargo of energy is lower per particle per boat so they’re doing their job and it suggests systemically that that’s exactly what they’re supposed to be doing so I have a ton of people writing in to me they’re going Dave I have the best inflammation markers I’ve ever seen I feel better than I ever have in my life but I’m freaking out because my LDL cholesterol is through the roof and it’s now to a point where if somebody sends me in a lab and it looks anything like this even before they tell me anything about them I go no it sounds like you’re lean and or athletic a you a lean mass hyper responder well yeah and then I send them to this and then more comments flow and so forth but once again this makes sense and what I want to direct your attention to is in order for me to be able to test this as the biohacker this is where I’m at currently this was the one thing that I knew I could change I could change my lower glycogen stores if I could up my glycogen stores so that my muscle in my liver were topped off more than theoretically my part my ldl-c should drop because I am on the cusp of being a lean mass hyper responder so this is my most recent experiment the energy status experiment which took place at Kido con and here’s what happened what I did was over seven days I had a keto shake because I’m so obsessive to be sure that I controlled all the variables I wanted to just be one variable a shake and so for the first three days for the washout period I had 3,000 calories of the shake I even ate to his schedule at 10:00 3:00 and 8:00 and then I just did one variable change I swapped in 500 calories of bread for day four and then swapped in a thousand calories of bread for day five but then stopped went back to the shake for two more days and unfortunately due to travel in the fact that I can’t travel with the oils that go with the shake I had to go back to just dieting but what do you suppose happened to my cholesterol over this period of time as you can see from here going all the way from the left I started at very high levels with adding the small carb increase past that point I was targeting to do it on my presentation and sure enough on that day my cholesterol dropped to the lowest it’s been since I’ve gone on keto now there’s a key thing I really want to emphasize which is I added the carbs a while ago so we know it’s not the composition of the diet that I needed to just keep eating carbs on every day because then it would theoretically change on the day or two after I changed back suggest that it’s an energy status the body now has a different energy status to what degree that’s glycogen stores it’s still somewhat theoretical but I’m pretty sure that that’s what it is that my body is going we have enough energy available to the cells that are in the form of glycogen we have less reason to up at the global supply of the energy and therefore less LDL so in summary cholesterol is not a driver it is a passenger is a passenger it rideshares with the energy you get from fat which you’re all on right now if you’re on a low carb diet and low density lipoproteins metabolic derangement can bring about higher LDL cholesterol for a bad reason it typically is leading to more small dense LDL unusual clue the usual clue is high triglycerides it’s also true about HDL but with HDL there can be genetic reasons and that’s kind of a deeper subject I won’t have enough time to get into but massive amounts of energy parked in the blood is a serious sign of dysregulation where the glucose or triglycerides that is like virtually and arguable you I don’t know of any scenario in which there’s a good reason from an engineering perspective that you should have a lot of energy sitting there so finally the inversion pattern which was the first part of my talk all things being equal LDL cholesterol will decrease with more dietary fat an increase with less dietary fat be aware of this if you’re doing multi day fasting coming up to a cholesterol test I highly don’t advise it unless you’re just trying to get a high score energy status the body appears less likely to traffic as many LDL particles when there are higher energy stores like glycogen right and then ensure basically I’m just saying look it’s all about the energy regulation that’s it I want to do a special thanks real quick to Siobhan and Craig they’ve been helping out helping me out a lot with cholesterol code and most importantly I want to do a special thanks to patrons because thank goodness for patreon.com I now have 52 people that are helping me out directly with being able to get my research forward so thanks again for that [Applause]

84 comments on “Dave Feldman – ‘It’s About Energy, Not Cholesterol’

  1. I wonder, if doctors look at the blood test results, how much of it is based on science
    and how much of it is based on opinion, observation, conclusion ?
    How many doctors will question their knowledge, after watching Dave's presentation ?

  2. Damn! I am sure the low fat advocates watching this, who has long argued that increasing dietary fat and dietary cholesterol will have an adverse effect on cholesterol levels, is shocked and chagrined by these results. Great job Mr. Feldman. This is why experimentation is absolutely necessary, because it works as a check to see if what our intuition leads us to believe is actually correct. As science has proven, time and time again, what our intuitions tell us, and what is reality, often contradict each other. Intuition would tell us that increased consumption of foods high in cholesterol should increase cholesterol in our blood, but as Feldman's experiments have illustrated, the body does not work in that simplistic fashion, to where it is the passive repository for whatever excesses we foist at it. I hope some pioneering doctor or researcher performs these experiments clinically and then publishes it in major journals, so that we can finally put the nail in the coffin of the "low fat equals good cholesterol" theory.

  3. It didn't come out and draw any conclusions on heart disease, but does this mean that doing an 18 hour fast a day and keto lowers my chances of heart disease? I'm very intolerant to statins, and I don't like their bad press in the first place, but I also don't want to die of a heart attack or stroke.

  4. What is the best way to prepare for a cholesterol test? Considering that I am catogenic. And all I'm interested in is the cholesterol test.
    1. Physical training before?
    2. Fat loading before?
    3. How close to testing?

  5. This talk is possibly the best talk to clarify what the whole cholesterol 'issue' is and the nonsense that surrounds the propaganda that goes with it.

  6. fantastic, plain english and simple analogy based explanation of the mysterious cholesterol and LDL panel and how a keto diet may influence those 'risk' factors.

  7. You to totally described me in my basketball days, LDL over 200 but HDL at 99… with low triglycerides.. fighting like hell to get back to that state.. great presentation

  8. Thank you I finally understand. Blood tests last month while fasting 24hours. So I should expect lol to be higher. Finally understand.

  9. Dave, from 17 min in to 22 min in was remarkable.  I had no idea thats how fat moved inside the body.   Great Video as a teaching tool, and I'm going to watch this again and again….

  10. How does someone break that barrier with our normal GP's to accept these higher than "normal" numbers? I was freaking out over seeing others talk about a 200% increase in lipid profile after keto. There is a lot of bad information out there on this. Thank you for clearing it all up.

    I'm not lean, yet. What if my lipid profile is high but I can't classify myself as "Lean Mass Hyper-Responder"? I'm at 4-months in ketosis and planing to get blood-work done very soon.

  11. I wish I had seen this video 3 days ago. This morning I had a blood test to see what my low carb diet is doing to my diabetes… In the previous 3 days I hadn't eaten much because I was testing my basal insulin…what do ya know… high LDL 212. Triglycerides. 103.

  12. I already commented in your other video, but this video. Wow.

    From 25:00 onward. LMHR. This blows my mind. The whole system blows my mind with how it works. And yet it works this way for a reason. "Harmonious" is the best term. You so are right.

    I can't get over how much this blows my mind. Yet makes sense in a way that should have been completely obvious already.

  13. Just a heads up to commenters here — if you're looking to reach out to me, the most common way is by commenting at my blog, CholesterolCode.com or via Twitter @DaveKeto. Cheers!

  14. Dave, have you worked with ME/CFS? I am 4 months Keto and my hitherto low cholesterol has shot up…. Yet my energy feels more stable on Keto. Great video, thanks for all you do.

  15. One point I don't understand… when you said "Hold On.. if you're metabolically unhealthy, this will not apply"… Do I understand from that.. that if I spent all my life being overweight and dieting and losing and gaining weight.. and my metabolism is all screwed up.. then I should not be doing Keto with the high fat intake.. because my body is not going to deal with it correctly.. like someone with a healthy metabolism?

  16. Hi Dave,isn't the body a hybrid system whereby it can derive energy from both/either fat or glucose?If so,why not eat foods from both sources as opposed to obsessing over being in ketosis at all times? Let me know your thoughts.Thanks✌

  17. This is fascinating. What I still don't understand is how a type 2 diabetic can lower their Triglycerides and raise their HDL. Anyone have any experience?

  18. God Belss You, Dave. This has been my issue all along. Maybe I can explain this to my doc and he'll stop trying to push the evil 'statans' on me. Thank you so much!

  19. Once again another great video! Over the years I prescribed a high fat/low carb diet for people who suffered from metabolic syndrome and obesity and it works wonders short term. However, there was a trend that I noticed with a lot of my clients who remained on the diet long term. I noticed that their levels of inflammation increased dramatically based on blood tests that measure inflammatory markers in the body (C Reactive Protein) is just one example. Not only that, but their kidney function was impaired based on testing and arthritis began to set in among other health issues like IBS. I never told them to remain on this type of diet long term as the negative would offset the positive at some point. However, the ones that did said they thought it was healthy since they were losing weight. My response to them was "a cancer patient will lose weight as well, but that doesn't mean they are healthy!"

    One diet I do know that works for the majority of people who don't want take things to extreme like the vegan or keto diets is to cut back or eliminate sugar! That simple! Eliminate simple sugar (no pun intended) or any food that contains sugar and you are already half way to the finish line. Your triglycerides will drop like a rock and so will your weight, not to mention your inflammation. Next, cut back on all foods that cause a high insulin response. Eat foods that are low on the Glycemic index and if you do eat a high GI food, take in some fiber or fat with it to slow down the absorption. Don't overeat as this tends to cause insulin resistance, and follow an intermittent fasting protocol.

    For example, eat two meals in an 8 hour window with no snacks in between and don't eat for 16 hours. In this example, you wake up at 7am and go to bed at 11pm. Your last meal should be no later than 7pm (4 hours before sleep) and your first meal should be no earlier than 11am (4 hours after you wake up). Most people can follow this along with eating a healthy plant based diet with minimal meat consumption along with proper daily exercise and live a long healthy life!

    What good is it to lower your cholesterol on a keto diet to simply cause severe inflammation in your body down the road and end up with cancer, and yes, even cardiovascular disease. How soon? Every person is different and it could take months or even years, but one thing for sure it will eventually catch up to you, and yes, I have proof based on my own client data of nearly 30 years! You could always eat like an Okinawan and live to a ripe old age of 100 or older and they eat very little meat! There is an old saying – eat dead foods and you will die! You want to eat foods that are thriving with enzymes and the last time I checked a dead cow, pig, etc. is not thriving! I know some people will lash out at this and to those people I say – what experience do you have? I have a client base of over 50,000 and have many physicians that use my research and tons of proof through tons of testing. Everything from blood work, urine, saliva, CIMT, ultrasounds, brain scans, CAT scans, MRIs, countless EKGs, echocardiograms, and so on! However, in my experience most people won't listen and they have to find out for themselves and usually won't do anything to change until after a heart attack, stroke, cancer, etc..

    Oh, I'm not the only expert in this field that has and continues to add researched backed data on what I'm saying. View this link for more info and consult with this large group of researchers and physicians and prolong your life by avoiding disease. https://www.antiagemedical.com/docs/Project150-Hand-out.pdf – Yes, I ramble on because I am passionate about my work and I think that's why I have a 2 year waiting list of clients. I do teach seminars 8 times per year in various parts of the country with other researchers and physicians that back my teachings and I do help people with emergency situations. I love helping people so I definitely don't promote anything or any product unless I know for a fact it works! In good health!

  20. I really would like to see a graph like the one in 23:45 for a metabolic UNHEALTHY situation.

    How do you guys think it would be?

  21. Nice Dave. I will definitely be following your work now. It is interesting to think through how you came to your conclusions.

  22. wrong perspective, wrong conclusions. also, cholesterol has little actual impact on heart health/strikes – all misleading.

  23. Your correlations may be even stronger than you think if you have not corrected for autocorrelation (typical for time series data). If you want to know how, just ask.

  24. Dave, Excellent way to make understand how energy distribution works in real! One question though, Dr. Peter Attia says or at least made me think listening to him on latest podcast with you is – high LDL is one of the 3 main reasons leading to atherosclerosis. Does that mean then, if I he is right, doing LCHF or Fasting is NOT good for heart? as they rise LDL. I currently erased/nullified every other negative marker for most of the major ailments by following LCHF. Just concerned still with LDL as per Dr. Attia's comments on LDL in relation to atherosclerosis. I am very interested in your perspective. Thanks again for one of the simple, honest, passionate and the best presentations ever done on Lipid energy distribution.

  25. @30:09 "Massive amounts of energy parked in the blood is a serious sign of dysregulation…" What # would be considered a massive amount?

  26. I'm on statins and my muscles ache like hell. I want to know what is going on, but I can't understand the science in this. Shame. Just tell me how to lower my cholesterol and get my doctor to take me off this poison.

  27. Why does ur calculator multiply mmol/l by 38.636 to get mg/dl for HDL, LDL etc and by 88.99 to get mg/dl for trigs? I thought the conversion was x 18

  28. Following your wonderful efforts on behalf of all of us hyper-responders—heartfelt thanks, Dave! I’ve been lowering carbs and sugar for 8 months, never having more than 2-10 pounds to lose and having worked out consistently throughout my adult life. Had my annual physical 3 weeks ago and my cholesterol shot up to 396…LDL was 313, Triglycerides were 62. Before my blood draw, I told my Dr I was expecting my LDL to be super high this year, but that I wasn’t going to be too concerned, given my change in diet. Having a CAC test today and my Dr wants new labs drawn in 6 months, at which time I am planning to follow your protocol.

  29. What a tour de force! Great information presented simply and clearly. I found the additional detail on the body's non-ketone fat usage extremely valuable.

  30. Hi Dave,isn't the body a hybrid system whereby it can derive energy from both/either fat or glucose?If so,why not eat foods from both sources as opposed to obsessing over being in ketosis at all times? Let me know your thoughts thanks!

  31. David deserves a special prize in science for the research he has done and the understanding he has shed/contributed to in the field of Cholesterol.
    Thanks David!

  32. Can taking a blood test 2 hours after a workout alter results in a bad way?

    For example:

    total cholesterol: 270

    LDL: 194

    HDL: 49

    TG: 128

  33. how are you going to "up your global energy supply" using LDL-C in a fasted state if the person is already lean mass? the only way to get more triglicerides is by eating via Chylomicrones unles the liver is a massive storage of triglicerides

  34. Would really love to see additional depth on correlations to: B-1, B-12, & HCl production… B-1 deficiency versus optimum & Carb intake to cholesterol result… same for B-12, …and while looking HCl (stomach acid)… B-1 (Thiamin(e)) is huge issue with carb consumption… very little serum testing being done…. B-12 also deep serum & other tests are rarely done

  35. Great video. But here is what I don’t understand. Q1) When we measure our LDL ( which are transport ships that contain triglycerides and cholesterol ) are we measuring the LDL ( the ship ) or the Cholesterol ? Q2) is HDL a different ship to LDL ? or is HDL contained in the LDL ship ?

  36. So if you wanted to game a cholesterol test (i.e. have low LDL), you should 1) eat enough fat and total calories in the three days prior (to downregulate LDL), 2) not be extremely lean (so that local adipose tissue can deliver energy instead of LDL), 3) eat enough glucose to top up muscle glycogen stores (so that skeletal muscle can get energy from local glycogen instead of LDL) 4) fast 12 hours before the test (to clear up remnants of dietary fat in the blood).

  37. I am constantly being chastised by doctors for refusing statin drugs. My total cholesterol is in the low to mid 300s. My HDL around 80. My triglycerides are around 70. Thank you for validating my position. I have a lot to learn so I'll keep watching. Thank you.

  38. check out Barbara O'Neill on blood, heart, cholesterol. Or Dr. John Bergman on same topic. Or Dr. Nadir Ali. You need cholesterol in its many forms in the metabolic pathway (cortisol, hormones); it ought never have been demonized (unless, say, you have a drug to sell that sounds a lot like Satin). The concern ought not be the messenger (cholesterol) but the stress and damage that calls cholesterol to be built up at the sites of damage (arterial walls) which is caused not by diet by other things, like smoking or vaccines/amalgams/mercury. As O'Neill says, just because the fire trucks are always at the fire, does not mean that the fire trucks caused the fire. Is it energy/diet or is it structural damage and inflammation that is at the heart of the "cholesterol debate"? In Dr Nadir Ali's talk on same topic he describes how excess will be removed via the bile and bowels. The human body is smarter than the human inhabiting it.

  39. I love this, unlike plant based channels you actually break down the mechanics of cholesterol and what it does. I recently listened to a “ sermon “ by Dr Klaper , and not an ounce of science, just his feelings on eating animals vs plants….

  40. Unless science is completely wrong, it is vldl that carries triglycerides, not ldl. LDL is basically what's left after most of the triglycerides have been distributed.

  41. Wow! …. Now I understand why my body requires certain amount of energy (heavy eating) at different times and less at some time …… All due to the work of the "Project Manager" a.k.a. the liver!

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